The Norwegian Scientific Committee for Food and Environment (VKM) leads the CHANGE project.

The “Collaboration to Harmonise the Assessment of Next Generation Evidence” (CHANGE) project is a new initiative that seeks to design system-level interventions for bringing forward the date of effective use of New Approach Methods (NAMs) in regulatory toxicology. CHANGE includes an international, interdisciplinary, and cross-sectorial group of actors from the regulatory toxicology community involved in several previous and ongoing projects and initiatives to support the shift towards implementation of NAMs.

CHANGE will host three annual workshops to i) explore (2024) the systemic structures of regulatory toxicology to identify barriers for implementation of NAMs deemed important by groups creating NAM data and the groups using the data and opportunities for interventions, ii) reflect (2025) on the importance for uptake and implementation of NAMs data in risk assessment and risk management to gain consensus on what is actually important, and iii) decide (2026) what should be done to break down the barriers by prioritising practically achievable steps for action and developing recommendations. Angela Bearth (HF Partners) is involved in the CHANGE project’s project team.

The project is supported by the Evidence-Based Toxicology Collaboration (EBTC) and the European Food Safety Authority (EFSA)​.